Aminoglycosides


These are products of actinomycetes (soil bacteria) or semi-synthetic derivatives of the natural products.

Examples are:

* streptomycin
* kanamycin
* neomycin
* gentamycin

The Chink in the Armor = the bacterial ribosome
The 70S bacterial ribosome differs in several ways from the 80S eukaryotic ribosome. [Link] The aminoglycosides bind to the 30S subunit of the bacterial ribosome and

* interfere with the formation of the initiation complex
* cause misreading of the mRNA.


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